Welcome to a new seminar series on the topic of Biomedical Engineering!

This seminar series is brought to you by the Division of Biomedical Engineering, Dept. Materials Science and Engineering and MedTech Science & Innovation Centre, with the aim of bringing together people at UU and beyond with an interest in biomedical engineering and to share news on the research that is going on across the university in this area.

The seminars will run during lunch time on the first Thursday of every month during term time and all are welcome to attend, in physical or digital format. A lunch sandwich will be served for those that attend in person. You can find more information about the individual seminars below.

Previous Seminar: 5 May 2022

Speaker: Professor Lorena Betancor, Department of Biotechnology, Faculty of Engineering, Universidad ORT Uruguay

Title: Biomimetic nanohybrids as nanoactuators for Enzyme Prodrug Therapy

Abstract: Nanohybrids harness the intrinsic characteristics of each individual material in a composite  that exhibits improved and new additional properties as a result of a synergetic effect of its structural builders. In this context, the synthesis of bio-nanohybrids based on biosilicification processes taking place in nature represents an extraordinary suitable approach compatible with enzyme immobilization due to its mild and fast synthetic approach (room temperature, neutral pH, free of organic solvents).

In this seminar I will we present a recently developed nanohybrid (nH) combining biomimetic silica (BioSi), magnetic nanoparticles (MNPs) and horseradish peroxidase enzyme (HRP), acting as core elements. The purpose of this nanocomposite is to combine the ability of MNPs to absorb energy in the presence of an external alternating magnetic field (AMF) and release it in the form of heat to locally reach the optimal HRP temperature via remote control. Triggering and modulation of the HRP activity may be used in Directed Enzyme Prodrug Therapy (DEPT) where a non-active prodrug is converted into a biologically active therapeutic molecule by enzyme activation. Details on the integration of each component of the nH will be discussed as well as its characterization and in vitro application in the remote enzyme activation.

Bio: Lorena Betancor is currently a Professor at the Department of Biotechnology at Universidad ORT Uruguay (Montevideo, Uruguay). Originally a Biochemist from Universidad de la República (Uruguay), she is a PhD from Universidad Autónoma de Madrid and has 4-year post-doc experience working first for the Oak Ridge Institute of Science and Education at the School of Civil and Environmental Engineer (Georgia Tech, Atlanta) and as a fellow of the Ministry of Science (Spain) at the Department of Biochemistry of the University of Cambridge (Cambridge, UK). She was also a research assistant at this University and a Ramón y Cajal fellow at Instituto Madrileño de Estudios Avanzados (Madrid, Spain) before returning to Uruguay. Her background lies in biocatalysis and enzyme immobilization with a particular focus in nanobiotechnology. She is the head of the Protein Technology group at ORT and is now focused on the use of biocatalysts immobilization for the development of environmentally friendly biocatalytic processes, biotechnological valorization of industrial byproducts, and biomedical applications.

Previous Seminar: 7 April 2022

Speaker: Assoc. Prof. Orcun Göksel, Department of Information Technology/MTSI, UU

Title: Deep Learning in Computer-assisted Diagnosis, Therapy, and Imaging

Abstract: This talk is aimed to serve as an overview of research interests in our group. With specific focus on combining imaging, image analysis, and learning systems, the talk will demonstrate several research topics and our recent developments therein; covering rather the breadth than the depth.  Several of our works revolve around ultrasound imaging, which is a safe, cost-effective, portable, and real-time imaging modality.  Its uses will be presented, for example, for elastography for characterizing shear-modulus and for speed-of-sound relating to bulk-modulus.  Several clinical applications, such as on biomechanical and imaging simulations for training and therapy, will also be exemplified.  An overarching theme throughout the talk will be our cutting-edge deep-learning solutions on the various research questions involved.

Bio: Orcun Goksel is associate professor at the Department of Information Technology at Uppsala University. He leads the research group Computer-assisted Applications in Medicine, as part of Uppsala Medtech Science and Innovation Centre and the Centre for Image Analysis. He received bachelor degrees in computer science and electrical engineering. Following a PhD degree from University of British Columbia, in Vancouver, Canada, he held a Swiss National Science Foundation Professorship at ETH Zurich, Switzerland, before joining Uppsala University. His research interests include machine learning, computer vision, ultrasound imaging in biomedical applications, biomechanical tissue characterization, image reconstruction, image-guided therapy, and patient-specific modelling and simulation. By devising novel imaging and image analysis techniques and developing them for clinical translation, his research efforts push the boundaries of diagnostic and surgical procedures as well as minimally-invasive interventions.

Assoc. Prof. Orcun Göksel

Organising Committee

Natalia Ferraz

I lead the NanoBiomaterials group at the Division of Nanotechnology and Functional Materials. Research activities in the NanoBiomaterials group are related with the development of nanostructured materials for biomedical applications. We focus on the use of application-oriented biocompatibility studies to evaluate the impact of nanomaterial design/modification/functionalization on the bioactivity of the material and the response of biological systems.

Read more about our ongoing research projects here: https://materialvetenskap.uu.se/nanotechnology-and-functional-materials/research-areas/nanobiomaterials/

Morteza Ararmesh

Morteza Aramesh received his PhD in (bio)physics from the University of Melbourne, Australia, where he studied functionalization of nanomaterials for biomedical applications, such as single-DNA sensors. He was a Marie-Curie postdoctoral fellow at ETH Zurich (Switzerland), where he was working on biosensors development for single-cell profiling. He held a Group Leader and Lecturer position at ETH Zurich, where he and his team studied mechanobiological cues to engineer cellular functions in immune cells for immunotherapy applications. He is currently holding a tenure-track Assistant Professorship at the Biomedical Engineering division of the Uppsala University, working on 3D biomaterials development for engineering cellular response in immune cells.

Last modified: 2022-05-17